The in-game version of 'Hericide' is a bit different with a heavier emphasis on the drums, which makes it even more awesome. Satan ( and Mega Satan) gets one of the most amazingly epic vocal tracks for his new battle theme: 'Hericide'.The theme of Mom's Heart/It Lives, 'Ventricide', which periodically switches between intense and creepy in a heartbeat.Mom gets the fast-paced and frantic 'Matricide' as her new battle theme, adding a strong sense of panic and urgency to the fight.While The Cellar has always been That One Level, 'Periculum', the driving rock theme that plays as you battle through it, more than makes up for it.'Crusade' is a rocking boss theme that prepares you for the various fights of this game.did not return for Rebirth, Ridiculon (Matthias Bossi and Jon Evans) performed excellently in his stead. It made #1 on Klagmar's 'Top 50 Final Boss Themes' it's that good. The theme for the boss of The Cathedral (and by extension, The Chest), the absolutely majestic Boss Remix of the main theme, 'My Innermost Apocalypse'.Lament of the Angel, a holy rearrangement of 'A Mourner Unto Sheol', counterbalancing the hellish Sheol itself with the Cathedral.And it's creepy as hell! Made worse by the fact that it's called ' Jesus Loves Me '. It comes as a great surprise because it replaces the BGM that usually plays on that sequence. The tune that plays on the credits after defeating It Lives! for the first time.It certainly shows that Sheol is cold, bleak, and empty. yet some parts are oddly soothing, to a point. The music that plays in Sheol, 'A Mourner Unto Sheol', is incredibly eerie and foreboding, to the point where it's arguably creepier than Rebirth's version.

Sheol's boss, on the other hand, has 'Enmity of the Dark Lord', which also does a fantastic job getting the player pumped up for the fight.The theme of Mom's Heart and It Lives, '.Be Done'.The theme for fighting Mom, 'Thine Wrath.', especially the parts where the chorus joins in showing that Isaac has a little hope.The normal boss theme, Divine Combat and the alternate theme, 'Crusade', both set a hectic feel for the first few boss battles.It helps that it's the background music for the first level, so it's going to worm its way into your ears at one point or another.

'Sacrificial', the Basement's theme, sets up the haunting atmosphere of the game quite nicely.

Completely captures the sinister, yet bright tone of the game.

The main theme (and arguably, Isaac's theme) of the game, 'The Binding of Isaac'.

The Binding of Isaac soundtrack was done by Danny Baranowsky, already well-known for his awesome video-game music, which includes such titles as Canabalt and Super Meat Boy.

The lamb binding of isaac